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Dott. Fabrizio Tabbo'

  • Dottorato: 28° ciclo
  • Matricola: 284925

Tesi di dottorato

The role of ALK in molecular characterization of Non Small Cell Lung Cancer

Attività di ricerca

Integrated multi-platform molecular characterization and development of innovative  patient-derived models for the clinical management of NSCLC and lymphoma patients.

  1. Tabbò F, Barreca A, Piva R, Inghirami G, European T-cell Lymphoma Study Group, ALK Signaling and Target Therapy in Anaplastic Large Cell Lymphoma. Front Oncol 2012;2:41.
  2. Rossi D, Trifonov V, Fangazio M, Bruscaggin A, Rasi S, Spina V, Monti S, Vaisitti T, Arruga F, Famà R, Ciardullo C, Greco M, Cresta S, Piranda D, Holmes A, Fabbri G, Messina M, Rinaldi A, Wang J, Agostinelli C, Piccaluga PP, Lucioni M, Tabbò F, Serra R, Franceschetti S, Deambrogi C, Daniele G, Gattei V, Marasca R, Facchetti F, Arcaini L, Inghirami G, Bertoni F, Pileri SA, Deaglio S, Foà R, Dalla-Favera R, Pasqualucci L, Rabadan R, Gaidano G., The coding genome of splenic marginal zone lymphoma: activation of NOTCH2 and other pathways regulating marginal zone development. J Exp Med. 2012 Aug 27;209(9):1537-51.
  3. Voena C, Di Giacomo F, Panizza E, D'Amico L, Boccalatte FE, Pellegrino E, Todaro M, Recupero D, Tabbò F, Ambrogio C, Martinengo C, Bonello L, Pulito R, Hamm J, Chiarle R, Cheng M, Ruggeri B, Medico E, Inghirami G., The EGFR family members sustain the neoplastic phenotype of ALK+ lung adenocarcinoma via EGR1. Oncogenesis. 2013 Apr 8;2. 
  4. Tabbò F, Ponzoni M, Rabadan R, Bertoni F, Inghirami G; European T-cell Lymphoma Study Group. Beyond NPM-anaplastic lymphoma kinase driven lymphomagenesis: alternative drivers in anaplastic large cell lymphoma. Curr Opin Hematol. 2013 Jul;20(4):374-81.
  5. Clozel T, Yang S, Elstrom RL, Tam W, Martin P, Kormaksson M, Banerjee S, Vasanthakumar A, Culjkovic B, Scott DW, Wyman S, Leser M, Shaknovich R, Chadburn A, Tabbo F, Godley LA, Gascoyne RD, Borden KL, Inghirami G, Leonard JP, Melnick A, Cerchietti L., Mechanism-based epigenetic chemosensitization therapy of diffuse large B-cell lymphoma. Cancer Discov. 2013 Sep;3(9):1002-19.
  6. Boi M, Rinaldi A, Kwee I, Bonetti P, Todaro M, Tabbò F, Piva R, Rancoita PM, Matolcsy A, Timar B, Tousseyn T, Rodríguez-Pinilla SM, Piris MA, Beà S, Campo E, Bhagat G, Swerdlow SH, Rosenwald A, Ponzoni M, Young KH, Piccaluga PP, Dummer R, Pileri S, Zucca E, Inghirami G, Bertoni F.,PRDM1/BLIMP1 is commonly inactivated in anaplastic large T-cell lymphoma. Blood. 2013 Oct 10;122(15):2683-93
  7. Pasqualucci L, Khiabanian H, Fangazio M, Vasishtha M, Messina M, Holmes AB, Ouillette P, Trifonov V, Rossi D, Tabbò F, Ponzoni M, Chadburn A, Murty VV, Bhagat G, Gaidano G, Inghirami G, Malek SN, Rabadan R, Dalla-Favera R., Genetics of follicular lymphoma transformation. Cell Rep. 2014 Jan 16;6(1):130-40.
  8. Caliò A, Nottegar A, Gilioli E, Bria E, Pilotto S, Peretti U, Kinspergher S, Simionato F, Pedron S, Knuutila S, Tortora G, Eccher A, Santo A, Tondulli L, Inghirami G, Tabbò F, Martignoni G, Chilosi M, Scarpa A, Brunelli M. ALK/EML4 fusion gene may be found in pure squamous carcinoma of the lung. J Thorac Oncol. 2014 May;9(5):729-32
  9. Cayrol F, Díaz Flaqué MC, Fernando T, Yang SN, Sterle HA, Bolontrade M, Amorós M, Isse B, Farías RN, Ahn H, Tian YF, Tabbò F, Singh A, Inghirami G, Cerchietti L, Cremaschi GA., Integrin αvβ3 acting as membrane receptor for thyroid hormones mediates angiogenesis in malignant T cells. Blood. 2015 Jan 29;125(5):841-51.
  10. Abate F, Todaro M, van der Krogt JA, Boi M, Landra I, Machiorlatti R, Tabbò F, Messana K, Abele C, Barreca A, Novero D, Gaudiano M, Aliberti S, Di Giacomo F, Tousseyn T, Lasorsa E, Crescenzo R, Bessone L, Ficarra E, Acquaviva A, Rinaldi A, Ponzoni M, Longo DL, Aime S, Cheng M, Ruggeri B, Piccaluga PP, Pileri S, Tiacci E, Falini B, Pera-Gresely B, Cerchietti L, Iqbal J, Chan WC, Shultz LD, Kwee I, Piva R, Wlodarska I, Rabadan R, Bertoni F, Inghirami G; European T-cell Lymphoma Study Group., A novel patient-derived tumorgraft model with TRAF1-ALK anaplastic large-cell lymphoma translocation. Leukemia. 2015 Jun;29(6):1390-401.
  11. Crescenzo R, Abate F, Lasorsa E, Tabbo' F, Gaudiano M, Chiesa N, Di Giacomo F, Spaccarotella E, Barbarossa L, Ercole E, Todaro M, Boi M, Acquaviva A, Ficarra E, Novero D, Rinaldi A, Tousseyn T, Rosenwald A, Kenner L, Cerroni L, Tzankov A, Ponzoni M, Paulli M, Weisenburger D, Chan WC, Iqbal J, Piris MA, Zamo' A, Ciardullo C, Rossi D, Gaidano G, Pileri S, Tiacci E, Falini B, Shultz LD, Mevellec L, Vialard JE, Piva R, Bertoni F, Rabadan R, Inghirami G; European T-Cell Lymphoma Study Group, T-Cell Project: Prospective Collection of Data in Patients with Peripheral T-Cell Lymphoma and the AIRC 5xMille Consortium “Genetics-Driven Targeted Management of Lymphoid Malignancies”, Convergent mutations and kinase fusions lead to oncogenic STAT3 activation in anaplastic large cell lymphoma. Cancer Cell. 2015 Apr 13;27(4):516-32.
  12. Pan H, Jiang Y, Boi M, Tabbò F, Redmond D, Nie K, Ladetto M, Chiappella A, Cerchietti L, Shaknovich R, Melnick AM, Inghirami GG, Tam W, Elemento O., Epigenomic evolution in diffuse large B-cell lymphomas. Nat Commun. 2015 Apr 20;6:6921

2013 - Integrated molecular characterization of Patient-Derived Tumorgrafts as innovative model for clinical management of Non-Small Cell Lung Cancer. 15° WCLC-IASLC, Sydney, Australia.

2014 - The coding genome of Nodal Marginal Zone Lymphoma reveals recurrent molecular alterations of PTPRD and other JAK/STAT signaling genes. 56° ASH Annual Meeting, San Francisco, USA.

2014 - Convergent mutations and new kinase fusions lead to oncogenic STAT3 activation in  Anaplastic Large Cell Lymphoma. 56° ASH Annual Meeting, San Francisco,  USA.

2013 - Humanized NOD/Scid/IL2γ-/- tumorgrafts recapitulate primary Anaplastic Large Cell Lymphoma. AACR Annual Meeting, Washington, USA.

2013 - Lesioni molecolari delle vie di segnale nelle linfoproliferazioni B-indolenti che mimano il linfoma splenico della zona marginale. 44° Congresso Nazionanle SIE, Verona, Italy.

2013 - Lenalidomide in associazione a Rituximab-CHOP21 (LRCHOP21) è fattibile ed efficace nei pazienti anziani affetti da linfoma diffuso a grandi cellule B alla diagnosi, indipendentemente dal profilo di origine cellulare: risultati a lungo termine dello studio di fase II REAL07 della fondazione italiana linfomi (FIL). 44° Congresso Nazionanle SIE, Verona, Italy.

2013 - B-RAF and ALK assessment in a subset of Pulmonary Enteric Adenocarcinomas. 6° Congresso Triennale SIAPEC-IAP, Roma, Italy

2013 -  Molecular Lesions of Signalling Pathways Genes in Indolent B-Cell Lymphoproliferations Mimicking Splenic Marginal Zone Lymphoma.  55° ASH Annual Meeting, New Orleans, USA.

2014 - Lung cancer biobanking: an integrated approach for precision medicine. 22° ESTS Annual Meeting, Copenhagen, Denmark.

2014 - Genetic Mechanisms of Immune Escape in Diffuse Large B Cell Lymphoma. 56° ASH Annual Meeting, San Francisco,  USA.

2010 - Italian participation to the european network of biobanking and biomolecular resources, Genoa, Italy

2011 - International IRCC Candiolo Conference “Molecular Clinical Oncology”, Turin, Italy

2012 - International Palermo Conference “Innovative therapies for lymphoid malignancies”, Palermo, Italy

2013 - American Association for Cancer Research (AACR) Annual Meeting, Washington, USA

2013    15th World Conference on Lung Conference (WCLC) - IASLC, Sydney, Australia

2014 - 2015 Postdoctoral research fellow, Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, USA 

Ultimo aggiornamento: 25/11/2015 15:07
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