Dottorato in Medicina Molecolare

1) Multifunctional core-shell nanoparticles: discovery of previously invisible biomarkers.Tamburro D, Fredolini C, Espina V, Douglas TA, Ranganathan A, Ilag L, Zhou W, Russo P, Espina BH, Muto G, Petricoin EF, Liotta LA, Luchini A. J Am Chem Soc. 2011 Nov 30;133(47):19178-88. Epub 2011 Nov 3

2) Proteomic analysis of panreatic ductal adenocarcinoma cells reveals metabolic alterations. Zhou W, Capello M, Fredolini C, Piemonti L, Liotta L, Novelli F, Petricoin E.J Proteome Res. 2011 Feb 10. [Epub ahead of print]

3) The use of hydrogel microparticles to sequester and concentrate bacterial antigens in a urine test for Lyme disease. Douglas TA, Tamburro D, Fredolini C, Espina BH, Lepene BS, Ilag L, Espina V, Petricoin EF 3rd, Liotta LA, Luchini A. Biomaterials. 2010 Oct 27.

4) Application of proteomic technologies for prostate cancer detection, prognosis, and tailored therapy. Fredolini C, Liotta LA, Petricoin EF.Crit Rev Clin Lab Sci. 2010 Sep 21. [Epub ahead of print]

5) Investigation of the ovarian and prostate cancer peptidome for candidate early detection markers using a novel nanoparticle biomarker capture technology. Fredolini C, Meani F, Luchini A, Zhou W, Russo P, Ross M, Patanarut A, Tamburro D, Gambara G, Ornstein D, Odicino F, Ragnoli M, Ravaggi A, Novelli F, Collura D, D'Urso L, Muto G, Belluco C, Pecorelli S, Liotta L, Petricoin EF 3rd. AAPS J. 2010 Dec;12(4):504-18.

6) Circulating Autoantibodies to Phosphorylated alpha-Enolase are a Hallmark of Pancreatic Cancer.Tomaino B, Cappello P, Capello M, Fredolini C, Sperduti I, Migliorini P, Salacone P, Novarino A, Giacobino A, Ciuffreda L, Alessio M, Nisticò P, Scarpa A, Pederzoli P, Zhou W, Petricoin Iii EF, Liotta LA, Giovarelli M, Milella M, Novelli F.J Proteome Res. 2010 Jun 10.

7) Mass spectrometry analysis of the post-translational modifications of alpha-enolase from pancreatic ductal adenocarcinoma cells. Zhou W, Capello M, Fredolini C, Piemonti L, Liotta LA, Novelli F, Petricoin EF.J Proteome Res. 2010 Jun 4;9(6):2929-36.

8) Nanoparticle technology: Amplifying the effective sensitivity of biomarker detection to create a urine test for hGH. Claudia Fredolini, Davide Tamburro, Guido Gambara, Ben Lepene, Virginia Espina, K. Alex Reeder, Sally Rucker, Lance Liotta and Alessandra Luchini Drug Test Anal. 2009 September; 1(9-10): 447–454. doi:10.1002/dta.96.

9) Nanoparticle technology: addressing the fundamental roadblocks to protein biomarker discovery. Luchini A, Fredolini C, Espina BH, Meani F, Reeder A, Rucker S, Petricoin EF 3rd, Liotta LA. Curr Mol Med. 2010 Mar;10(2):133-41. Review.

10) Core-shell hydrogel particles harvest, concentrate and preserve labile low abundance biomarkers. Longo C, Patanarut A, George T, Bishop B, Zhou W, Fredolini C, Ross MM, Espina V, Pellacani G, Petricoin EF 3rd, Liotta LA, Luchini A. PLoS One. 2009;4(3):e4763. Epub 2009 Mar 10.

11) Concentration and Preservation of Very Low Abundance Biomarkers in Urine, such as Human Growth Hormone (hGH), by Cibacron Blue F3G-A Loaded Hydrogel Particles. Fredolini C, Meani F, Reeder KA, Rucker S, Patanarut A, Botterell PJ, Bishop B, Longo C, Espina V, Petricoin EF, Liotta LA, Luchini A. Nano Res. 2008 Dec;1(6):502-518.

12) Laser capture microdissection and protein microarray analysis of human non-small cell lung cancer: differential epidermal growth factor receptor (EGPR) phosphorylation events associated with mutated EGFR compared with wild type. VanMeter AJ, Rodriguez AS, Bowman ED, Jen J, Harris CC, Deng J, Calvert VS, Silvestri A, Fredolini C, Chandhoke V, Petricoin EF 3rd, Liotta LA, Espina V. Mol Cell Proteomics. 2008 Oct;7(10):1902-24.

13) Autoantibody signature in human ductal pancreatic adenocarcinoma.Tomaino B, Cappello P, Capello M, Fredolini C, Ponzetto A, Novarino A, Ciuffreda L, Bertetto O, De Angelis C, Gaia E, Salacone P, Milella M, Nisticò P, Alessio M, Chiarle R, Giuffrida MG, Giovarelli M, Novelli F.J Proteome Res. 2007 Oct;6(10):4025-31.

1) HUPO 9th Annual World Congress 19-23 September,2010 Sidney Incorporation of a new class of dye based affinity baits in sieving hydrogel nanoparticles overcome roadblocks to cancer biomarker discovery. Davide Tamburro1,2, Claudia Fredolini1,2, Temple Douglas1 , Virginia Espina1, Alessandra Luchini1 ,Emanuel F. Petricoin III1, and Lance Liotta1. (1 Center for applied Proteomics and Molecular Medicine George Mason University, 2 Istituto Superiore di Sanita Roma Italy.

2) HUPO 9th Annual World Congress 19-23 September,2010 Sidney A Novel Nanoparticle-Coupled MALDI-TOF Approach for High Throughput Low Molecular Weight Biomarker Enrichment, Isolation, Preservation and Discovery Brian Feild, Benjamin Lepene, Claudia Fredolini,  Benjamin S. Espina, Davide Tamburro, Alessandra Luchini, Barney Bishop, Emanuel Petricoin, Lance Liotta, Scott Kuzdzal.

3) 51° CONGRESSO NAZIONALE DELLA SOCIETA' ITALIANA DI CANCEROLOGIA - 23-26 NOVEMBRE 2009., Sesto San Giovanni, Milan, Italy.Smart nanoparticles for the discovery and validation of cancer associated biomarkers. Claudia Fredolini, Davide Tamburro, Virginia Espina, Emanuel F Petricoin, Lance A Liotta, Alessandra Luchini.

4)  AACR Annual Meeting Washington,DC April 17-21 2010  Mass spectrometry analysis of the posttranslational modifications of alpha-enolase from pancreatic ductal adenocarcinoma cells  Weidong Zhou, Michela Capello, Claudia Fredolini, Francesco Novelli, Lance A. Liotta, Emanuel F. Petricoin.

 5) AACR Annual Meeting  Washington, DC April 17-21 2010  Verification of prostate cancer biomarker candidates by nanoparticle-capture MRM  Claudia Fredolini, Alessandra Luchini, Francesco Meani, Paul Russo, Davide Tamburro, Temple Douglas, Caterina Longo, Guido Gambara1, Weidong Zhou, Mark Ross, Francesco Novelli, Devis Collura, Giovanni Muto, Virginia Espina, David Ornstein, Lance A. Liotta, Emanuel F. Petricoin III.

 6) 238th American Chemical society National Meeting & Exposition August 16-20 , 2009 Washington DC, USA. Synthesis and screening against relevant tumor associated biomarkers of hydrogel nanoparticles functionalized with dye-based baits. Davide Tamburro, Alessandra Luchini, Claudia Fredolini, Temple Douglas, Alexis Patanarut, Barney Bishop, Ginny Espina, Francesco Facchiano, Emanuel F. Petricon III and Lance Liotta

 7) AACR Annual Meeting 2009 Denver, CO April 18-22 2009  BAIT LOADED HYDROGEL PARTICLES PERFORM ONE STEP, IN SOLUTIONSEQUESTRATION, CONCENTRATION AND PROTECTION FROM DEGRADATION OF LOWMOLECULAR WEIGHT, LOW ABUNDANCE DISEASE BIOMARKERS IN BLOOD AND URINE Alessandra Luchini*, Caterina Longo, Claudia Fredolini, Francesco Meani, Davide Tamburro, Virginia Espina, Palma J Botterell, Alexis Patanarut, Barney Bishop, Weidong Zhou, Mark M Ross, Emanuel F Petricoin III, Lane A Liotta

 8) AACR Annual Meeting 2009 Denver, CO April 18-22 2009  Fredolini Claudia Akrita Bhatnagar, Weidong Zhou, Mark Ross, Davide Tamburro, Francesco Novelli, Devis Collura, Giovanni Muto, Virginia Espina,David Ornstein, Emanuel F. Petricoin III and Lance Liotta. A novel technological approach for the discovery of low molecular weight serum biomarkers based on “smart” hydrogel nanoparticles applied to prostate cancer.

 9) AACR Annual Meeting 2009 Denver, CO April 18-22 2009 Alessandra Luchini, Virginia Espina, Claudia Fredolini, Davide Tamburro, Benjamin Espina, Alex Reeder, Lindsay Wescott, Alexis Patanarut, Barney Bishop, Benjamin Lepene, Emanuel F Petricoin III, Lance A Liotta. Smart nanoparticles overcome basic  roadblocks  to biomarker discovery and validation.

10) XLIX Annual meeting of the Italian  Cancer Society ;Pordenone ;Italy  November 26-29 2007 Tomaino B.,Cappello P., Capello M., Ciccarelli M., Fredolini C., Migliorini P., Novarino A., Ciuffreda L., Giuffrida M.G.,  Alessio M., Nisticò P.,Giovarelli M., Milella M., and Novelli F. ^,“Autoantibodies to a -enolase isoforms as diagnostic and prognostic markers in pancreatic cancer”.

11) Piemonte Proteomic: Acquisition and development within the Environmental, Clinical and Alimentary  ambit.  Fondazione per le Biotecnologie, Turin, Italy. January 20, 2006:B. Tomaino, P. Cappello, M. Capello, C. Fredolini, C. Medana, M. Alessio, A. Ponzetto, M. Giovarelli and F. Novelli “Tumoral antigens in  pancreatic cancer, biochemical characterization of a-enolase”

 12) Italian proteome Society, Proteomics and Genomics, Second Congress, Viterbo, Italy.  May 29-1 June, 2005: B. Tomaino, P. Cappello, M. Capello, C. Fredolini, C. Medana, M. Alessio, A. Ponzetto, M. Giovarelli and F. Novelli“Identification of tumor associated antigens in pancreatic cancer by serological proteome analysis (SERPA)”.

 13) Proteomics and Bioinformatics; Systems and Biology, Keystone Simposia, Keystone, Colorado, USA. April 8-13, 2005: B. Tomaino, P. Cappello, M. Capello, C. Fredolini, C. Medana, M. Alessio, A. Ponzetto , M. Giovarelli and F. Novelli “Identification of tumor associated antigens in pancreatic cancer by serological proteome analysis (SERPA)”.

1) 51° CONGRESSO NAZIONALE DELLA SOCIETA' ITALIANA DI CANCEROLOGIA - 23-26 NOVEMBRE 2009., Sesto San Giovanni, Milan, Italy.

2) AACR Annual meeting 2010, Washington DC, April 17-21 2010

3) AACR Annual meeting 2009,Denver CO,april 18-22 2009

4) US HUPO 4th Annual Conference Bethesda, Maryland, USA . March 16-19, 2008

5) Stat Factors and Cancer minisymposium, Torino, Italy October 15, 2007.

6) Proteomix: “Mix your knowledge to get more” Discussion group about proteomic and mass spectrometry. Rimini ,Italy. May 11-12, 2006

7) Piemonte Proteomic: Acquisition and development within the Environmental, Clinical and Alimentary  ambit.  Fondazione per le Biotecnologie, Turin, Italy. January 20, 2006

8) 9th Biotechnology National Congress: Translational Models in Biotecnology, Torino, Italy September 7-9, 2006.

9) International Meeting HPV and Cancer, Torino, Italy November 10, 2006.

March 2008- Today

Research Scholar at George Mason University , Manassas VA ,USA.