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Alessandra Maria Adelaide Chiotto

Tesi di dottorato

During my Master in Molecular Biotechnology, I've worked with animal models, cell cultures, primary hippocampal and cortical neurons.

My thesis was focused on the analysis and the involvment of different proteins in many aspects of neuronal development, both in vivo and in vitro.

Attività di ricerca

I am interested in the characterization of different pathways that are involved in the first stages of neuronal differentiation, particularly on cytoskeleton regulating proteins.

I'm currently working on the mechanisms involved in neuronal defects present in Down syndrome mouse mode.

I am currently working on the cortical defects that characterize Down Syndrome

  • Di Gregorio, Eleonora; Bianchi, Federico T.; Schiavi, Alfonso; Chiotto, Alessandra M. A.; Rolando, Marco; di Cantogno, Ludovica Verdun; Grosso, Enrico; Cavalieri, Simona; Calcia, Alessandro; Lacerenza, Daniela; Zuffardi, Orsetta; Retta, Saverio Francesco; Stevanin, Giovanni; Marelli, Cecilia; Durr, Alexandra; Forlani, Sylvie; Chelly, Jamel; Montarolo, Francesca; Tempia, Filippo; Beggs, Hilary E. “A de novo X;8 translocation creates a PTK2-THOC2 gene fusion with THOC2 expression knockdown in a patient with psychomotor retardation and congenital cerebellar hypoplasia” Journal of Medical Genetics;Aug2013, Vol. 50 Issue 8, p543

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"Cell-autonomous vs non cell-autonomous cortical defects in a mouse model of Down syndrome"Chiotto A.M.A.*1, Berto G.E.*1, Agosto M.1, Fiore J.1, Bianchi F.T.1 , Gai M.1, Sgrò F.M.1 , Di Cunto F.  at Trisomy 21 Research society 1st Meeting

"Cell-autonomous vs non cell-autonomous cortical defects in a mouse model of Down syndrome"Chiotto A.M.A.*1, Berto G.E.*1, Agosto M.1,  Bianchi F.T.1 , Gai M.1, Sgrò F.M.1 , Di Cunto F.  at Neuronal Cytoskeleton Workshop 

“Role of TTC3 dependent RhoA signalling dysregulation in Ts65Dn cortical phenotypes.” Chiotto A.M.A, Berto G.E., Iampietro C, Bianchi F.T., Gai M, Sgrò F.M., Di Cunto F. " at Neuronal development and neuronaldevelopmental disorders.

RELEVANCE OF THE AXONAL SMN PROTEIN (A-SMN) FOR SPINAL MUSCULAR ATROPHY: NOVEL CELL MODELS, TRANSGENIC MICE AND THERAPEUTIC APPROACHES. Locatelli Denise (1), Terao Mineko (2), Zanellati Maria Clara (1), Pletto Daniela (1), Berto Gaia (3), Chiotto Adelaide (3), Pallavicini Gianmarco (3), Di Cunto Ferdinando (3), Turco Emilia (3), Garattini Enrico (2), Battaglia Giorgio Stefano (1)

IDENTIFICATION OF THERAPEUTIC TARGETS IN PRIMARY MICROCEPHALY THROUGH THE ANALYSIS OF THE CIT-K/ASPM PATHWAY  Gai Marta (1), Bianchi Federico (1), Sgrò Francesco (1), Berto Gaia (1), Falcone Mattia (1), Chiotto Adelaide (1), Pallavicini Gianmarco (1), Turco Emilia (1), Chang YoonJeung (2), Priano Lorenzo (3), Mauro Alessandro (3), El Assawy Nadia (3), Huttner Wieland (2), Di Cunto Ferdinando (1)

5/7-9/7 2014  9th FENS forum of Neuroscience, Milan

22/9-26/9 2014  Course: “Neural development and neuro-developmental disorders”  NENS course, Turin.

3/10/14  Workshop “Allen Institute for Brain Science Informational Overwiew And Training Workshop”, Turin,Neuroscience Department.

22-26/03/15: EMBO workshop “Emerging concepts of the neuronal cytoskeleton”, Puerto Varas,Chile 

04-07/06 2015:“1st International conference of the Trisomy 21 research society”, Paris, France

07-09/04 2016:  ABCD Salerno

July 2012-October 2012: Visiting student at Prof. Casper C. Hoogenraad Lab, Utrech, Netherland

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