Dottorato in Medicina Molecolare

Palomero L, Galvan-Femenìa I, de Cid R, Espın R, Barnes DR, CIMBA, Blommaert E, Gil-Gil M, Falo C, Stradella A, Ouchi D, Roso-Llorach A, Violan C, Pena-Chilet M, Dopazo J, Extremera AI, Garcıa-Valero M, Herranz C, Mateo F, Mereu E, Beesley J, Chenevix-Trench G, Roux C, Mak TW, Brunet J, Hakem R, Gorrini C, Antoniou AC, Lazaro C and Pujana MA. (2020) Immune Cell Associations with Cancer Risk. iScience 23, (2020). [DOI PMID]

Mucciolo G, Roux C, Scagliotti A, Brugiapaglia S, Novelli F, Cappello P. (2020) The dark side of immunotherapy: pancreatic cancer.  Cancer Drug Resist 2020;3. [DOI]

Roux C, Jafari SM, Shinde R, Duncan G, Cescon DW, Silvester J, Chu MF, Hodgson K, Berger T, Wakeham A, Palomero L, Garcia-Valero M, Pujana MA, Mak TW, McGaha TL, Cappello P, Gorrini C. (2019) Reactive oxygen species modulate macrophage immunosuppressive phenotype through the up-regulation of PD-L1. Proceedings of the National Academy of Sciences of the United States of America 116(10) 4326-4335 [DOIopen_in_new  PMIDopen_in_new]

Kubli SP, Bassi C, Roux C, Wakeham A, Gobl C, Zhou W, Jafari SM, Snow B, Jones L, Palomero L, Thu KL, Cassetta L, Soong D, Berger T, Ramachandran P, Baniasadi SP, Duncan G, Lindzen M, Yarden Y, Herranz C, Lazaro C, Chu MF, Haight J, Tinto P, Silvester J, Cescon DW, Petit A, Pettersson S, Pollard JW, Mak TW, Pujana MA, Cappello P, Gorrini C. (2019) AhR controls redox homeostasis and shapes the tumor microenvironment in BRCA1-associated breast cancer. Proceedings of the National Academy of Sciences of the United States of America 116(9) 3604-3613 [DOIopen_in_new  PMIDopen_in_new]

Cappello P, Curcio C, Mandili G, Roux C, Bulfamante S, Novelli F. (2018) Next Generation Immunotherapy for Pancreatic Cancer: DNA Vaccination is Seeking New Combo Partners. Cancers 10(2) [DOIopen_in_new  PMIDopen_in_new]

Roux C, Riganti C, Borgogno SF, Curto R, Curcio C, Catanzaro V, Digilio G, Padovan S, Puccinelli MP, Isabello M, Aime S, Cappello P, Novelli F. (2017) Endogenous glutamine decrease is associated with pancreatic cancer progression. Oncotarget 8(56) 95361-95376 [DOIopen_in_new  PMIDopen_in_new]

Chattaragada MS, Riganti C, Sassoe M, Principe M, Santamorena MM, Roux C, Curcio C, Evangelista A, Allavena P, Salvia R, Rusev B, Scarpa A, Cappello P, Novelli F. (2018) FAM49B, a novel regulator of mitochondrial function and integrity that suppresses tumor metastasis. Oncogene 37(6) 697-709 [DOIopen_in_new  PMIDopen_in_new]

Capello M, Ferri-Borgogno S, Riganti C, Chattaragada MS, Principe M, Roux C, Zhou W, Petricoin EF, Cappello P, Novelli F. (2016) Targeting the Warburg effect in cancer cells through ENO1 knockdown rescues oxidative phosphorylation and induces growth arrest. Oncotarget 7(5) 5598-612 [DOI PMID]

 

Cappello P, Mucciolo G, Curto R, Roux C, Curcio C, Vannucci L, Novelli F.  "The absence of IL-17 prolongs survival in pancreatic cancer by switching fibrosis from pro-tumoral to wound healing like." EACR-AACR-SIC 2017, Firenze

Roux C, Curto R, Mucciolo G, Novelli F, Mak T.W and Cappello P. "Pancreatic cancer-related inflammation: in vivo screening to identify key targetable molecules." SIICA 2017, Bari

Roux C, Curto R, Mucciolo G, Novelli F, Mak T.W and Cappello P. "Pancreatic cancer-related inflammation: in vivo screening to identify key targetable molecules." EACR-AACR-SIC 2017, Firenze. 

Curcio C, Mucciolo G, Curto R, Roux C, Vannucci L, Novelli F and Cappello P. "IL-17affects pancreatic cancer progression by modulating stromal cells." CRI-CIMT-EATI-AACR 2017, Mainz.

Roux C, Curto R, Mucciolo G, Novelli F, Mak T.W and Cappello P. "Pancreatic cancer-related inflammation: in vivo screening to identify key targetable molecules." SIICA PhD Retreat 2017, Verona.

Roux C, Curto R, Mucciolo G, Novelli F, Mak T.W and Cappello P. "Pancreatic cancer-related inflammation: in vivo screening to identify key targetable molecules." Oral presentation. Riunione Scuola Dianzani 2017, Novara. 

Mucciolo G, Curto R, Curcio C, Roux C, Vannucci L, Novelli F and Cappello P. "IL-17 induces myeloid-related stimulating factors by stromal cells." AACR Annual Meeting 2018; April 14-18, 2018; Chicago, IL.

Kubli SP, Bassi C, Roux C, Wakeham A, Baniasadi SP, Palomero L, Thu K, Cassetta L, Soong D,  Berger T, Herranz C, Göbl C, Silvester JS, Pollard JW, Pujana MA, Mak TW, Cappello P and Gorrini C. "Aryl hydrocarbon Receptor orchestrates oxidative stress and macrophage functions in BRCA1-associated cancers." CSHL Mechanism and Modeling of Cancer 2018, Cold Spring Harbour.

Roux C, Moghadas Jafari S, Shinde R, Duncan G, Cescon DW, Silvester J, Chu M.F, Hodgson K, Berger T, Wakeham A, Palomero L, Garcia-Valero M, Pujana M.A, Mak TW, McGaha TL, Cappello P, Gorrini C. "Reactive oxygen species modulate macrophage immunosuppressive phenotype through the up-regulation of PD-L1". Oral presentation. SIICA- DGfI 2019, Munich. 

Mucciolo G, Curcio C, Roux C, Curto R, Barutello G, Brugiapaglia S, Scagliotti A, Novelli F and Cappello P. "The IL17 ablation improves specific anti-tumor immune response". SIICA- DGfI 2019, Munich.

Kubli S, Roux C, Gobl C, Bassi C, Palomero L, Thu K, Cassetta L, Soong D, Herranz C, Pollard JW, Pujana MA, Mak TW, Cappello P and Gorrini C. "The Redox Regulation of Tumor Microenvironment in BRCA1-associated Breast Cancer". Benzon Symposium 65 2019– “Targeting Breast and Ovarian Cancers: From Basic Research to Novel Treatment Strategies”, Copenhagen.

Curcio C, Roux C, Conti L, Curto R, Brugiapaglia S, Scagliotti A, Ghigo A, Cappello P, Hirsch E and Novelli F. "Pancreatic cancer therapy based on combination of DNA vaccination and PI3Kgamma inhibition". Fifth CRI-CIMT-EATI-AACR International Cancer Immunotherapy Conference: Translating Science into Survival 2019, Paris.

Curcio C, Roux C, Conti L, Curto R, Mucciolo G, Bulfamante S, Brugiapaglia S, Scagliotti A, Ghigo A, Cappello P, Giovarelli M, Hirsch E and Novelli F "Pancreatic cancer therapy based on combination of DNA vaccination and PI3Kgamma inhibition". XV Riunione Scientifica della Scuola Dianzani 2019, Meccanismi molecolare nella patogenesi delle malattie, Genova (IT).

Roux C, Mucciolo G; Kopecka J, Scagliotti A, Brugiapaglia S, Curto R, Riganti C and Cappello P. Abstract title: "IL17A depletion affects metabolism of macrophages treated with gemcitabine". CSHL Virtual meeting 2020, Mechanism and Model of Cancer.

Mucciolo G, Curcio C, Roux C, Curto R, Barutello G, Brugiapaglia S, Scagliotti A, Novelli F, Cappello P. Abstract title: "Interleukin 17 depletion: a promising adjuvant strategy to increase DNA-vaccination efficacy in Pancreatic Ductal Adenocarcinoma treatment". CSHL Virtual meeting 2020, Mechanism and Model of Cancer. 

Curcio C, Roux C, Conti L, Curto R, Mucciolo G, Bulfamante S, Brugiapaglia S, Scagliotti A, Ghigo A, Cappello P, Hirsch E, Novelli F. “Pancreatic cancer therapy based on combination of DNA vaccination and PI3Kgamma inhibition”. SITC 2020.

May 25^th-28^th, 2016. X National Congress of SIICA, Abano Terme (Padova, Italy), Poster presentation

May 26^th-28^th, 2017. Advanced School of Immunology organized by SIICA, Bari (Italy)

May 28^th-31^st, 2017. XI National Congress of SIICA, Bari (Italy), Poster presentation

June 24^th-27^th, 2017. EACR-AACR-SIC 2^nd Special Conference, Firenze (Italy), Poster presentation

October 6^th-7^th, 2017. International Retreat of PhD students in Immunology, Verona (Italy), Poster presentation

November 16^th-17^th, 2017. Scientific Retreat Dianzani School, Novara (Italy) - Presenting author

August 14^th-18^th, 2018. Mechanism and Models of Cancer Meeting, Cold Spring Harbor Laboratory (NY, USA), Poster presentation

Sept 10^th-13^th, 2019. II Joint meeting SIICA- DGfI, Munich (Germany), Oral presentation

August 11th-14th, 2020. Mechanism and Models of Cancer Virtual Meeting, Cold Spring Harbor Laboratory (NY, USA), Poster presentation

 

4 October 2016, Aula Magna, Cavallerizza Reale, Via Giuseppe Verdi 9, Turin (IT). “Giornata dedicata alla valorizzazione delle competenze dei dottorandi di ricerca e del postdoc”. Dr. Marco Degani.

21 December 2016, Aula CeRMS, via Santena 5, Torino (IT). “Unveiling Control of Th Polarization: Response to Needs” Dr. Raffaele de Palma (Ospite: F. Novelli).

19-20 January 2017, Human Genetics Foundation – HuGeF, Turin (IT). “First HuGeF workshop on Precision Medicine” Dr. Gianluca Severi.

23 January 2017, Aula CeRMS, via Santena 5, Torino (IT). “MEF2C: a Molecular Switch for Multiple Cellular Processes” Dr. Susanna Molinari (Ospite: C. Ponzetto).

28 February 2017, MBC, via Nizza 52, Torino (IT). “PI3K delta Blockade Increases Genomic Instability in B cells” Dr. Mara Compagno (Ospite: M. Brancaccio).

12 April 2017, Sala Multifunzionale, Cavallerizza Reale, Via Giuseppe Verdi 9, Turin (IT). “Preparing your next Professional Step”, Association Bernard Gregory, ABG, Paris (FR). Dr. Marco Degani.

22 May 2017, Molecular Biotechnology Center, Aula Darwin, Via Nizza 52, Turin (IT). “Giornata di Studio Guido Tarone”.

23 May 2017, Aula CeRMS, Via Santena 5, Turin (IT). “Basic Flow cytometry” organized by Miltenyi Biotec Dr. Adamo Diamantini.

21 June 2017, Aula CeRMS, via Santena 5, Torino (IT). “The NIH PREVENT cancer program” Dr. Shizuko Sei (Ospite: F. Novelli).

19 September 2017, Molecular Biothecnology Centre (MBC), Via Nizza 52, Turin (IT). “D-Day 2017” organized by Scuola di Dottorato in Scienza della Vita e della Salute, Prof.ssa Mirella Giovarelli.

30 November 2017, Molecular Biothecnology Centre (MBC), Via Nizza 52, Turin (IT). ImageJ Course.

November 2017, ECM rif. 320 – 201079 “La ricerca preclinica e l’approccio multidisciplinare nel tumore del pancreas: vantaggi e opportunità nella pratica clinica”, Turin (IT).

September 20, 2018. Dr. Alan Ashworth, PhD, FRS. “Synthetic Lethal Approaches to Cancer Therapy” Princess Margaret Cancer Centre, 610 University Avenue. Dr. Bob Bell Auditorium, 6th floor, Room 604

February 26, 2019. Ruoshi Shi (Kelly), Tsao Lab “Establishment of non-small cell lung cancer organoids for disease modelling”. TMDT 101 College Street, suite 4-204

February 26, 2019. Dr. Nikolina Radulovich (Organoids Core) “Patient-Derived Organoid Models at Princess Margaret Living Biobank”. TMDT 101 College Street, suite 4-204

March 4, 2019. Dr. Arnold J. Levine, Ph.D. “The Role of Truncal Initiating Mutations in Cancer: Order Matters”. Princess Margaret Cancer Centre, 610 University Avenue. Dr. Bob Bell Auditorium, 6th floor, Room 604

March 5, 2019. Dr. Daniel K. Nomura. “Reimagining Druggability using Chemoproteomic Platforms”. Princess Margaret Cancer Centre 610 University Avenue 7th Floor Conference, Room 7-605

March 7, 2019. Dr. David Barbie, M.D. - Dana-Farber Cancer Institute. “Mechanisms of Immune Evasion in KRAS-LKB1 Mutant Lung Cancer”. Princess Margaret Cancer Centre 610 University Avenue 7th Floor Conference, Room 7-605

March 26, 2019. Dr. Sara Lamorte “Apototic cell clearance promotes tumor tolerance”. Princess Margaret Cancer Centre, 610 University, Till and McCulloch Conference Room, 8th Floor, Room 8-502.

March 26, 2019. Mat Brevard, Co-Founder and CEO, Emit Imaging & Mohammed Farhoud, VP, Sales & Marketing, Emit Imaging. “Cryo-Fluorescence Tomography, A Technique to Bridge Multi-Resolution Multi-Modal Assays”. 101 College Street, Princess Margaret Cancer Research Tower, 4th Room, Rm 4-204.

April 2, 2019.  Dr. Brett Wang “Development of immune therapy targeting WT1 peptides presented by HLA class II molecules”. Princess Margaret Cancer Centre, 610 University, Till and McCulloch Conference Room, 8th Floor, Room 8-502.

April 2, 2019. Dr. Priya Makhijani “Pancreatic tumor-derived exosomes and systemic immune dysfunction”. Princess Margaret Cancer Centre, 610 University, Till and McCulloch Conference Room, 8th Floor, Room 8-502.

April 9, 2019. James Chan “The role of GITRL-GITR system in Malignant Pleural Mesothelioma (MPM)”. Princess Margaret Cancer Centre, 610 University, Till and McCulloch Conference Room, 8th Floor, Room 8-502.

April 9, 2019. Teresa Ciudad Garcia “STING activation in pancreatic macrophages drives inflammation during Type 1 Diabetes in response to β-cell death”. Princess Margaret Cancer Centre, 610 University, Till and McCulloch Conference Room, 8th Floor, Room 8-502.

June 18, 2019. Dr. Mark M. Davis “Tools for T cells:  from single cells to specificity in autoimmunity, infectious diseases and cancer.” Princess Margaret Cancer Centre, 610 University Avenue, Dr. Bob Bell Auditorium, 6th floor, Room 604.

July 5th, 2019. MACS® Immuno-Oncology Day, “New frontiers in cancer immunotherapy". Politecnico di Torino - Aula Magna Giovanni Agnelli.

September 30, 2019. D-Day, Mrs. Mary K. Kobia University of Copenhagen “Strategic Program for PhDs – Talent management and talent attraction. Mobility Program and Career Development activities to help doctoral students prepare for their postdoctoral path”.

September 30, 2019. D-Day, Prof. Giannino Del Sal University of Trieste and LNCIB, Trieste “p53 at the crossroads of mechano-signalling and metabolic pathways in cancer”

October 7, 2019. Mahmoud Bassal, PhD. Webinar “scRNA-Seq paired with high‑speed cell sorting reveals previously hidden quiescent stem cell subset within rare HSPC population”

October 11, 2019. “Nuove sinergie al servizio del paziente con tumore del pancreas”

October 25, 2019. “Horizon Europe and Project Writing”. Room "Arturo Graf", in the Arturo Graf Library, Palazzo del Rettorato, Via Po 17.

November 29, 2019. Sara Bulfamante, Immunology Seminar. “Chemotherapy potentiates tumor vaccination in PDA preclinical model. Laura Conti, Immunology Seminar. “The immunotargeting of the xCT cystine/glutamate antiporter potentiates the efficacy of Her2-targeted immunotherapies in breast cancer”.

December 4, 2019. Andrea Graziani, PhD. Seminar MBC, Torino. “The emerging role of Diacylglycerol kinases in immmunity and cancer. A novel target for immunotherapy?”

December 20, 2019. Gianluca Mucciolo, Immunology Seminar. “ECM-associated proteins in PDAC microenvironment”. Roberto Ruiu, Immunology Seminar. “Investigating the cystine/glutamate antiporter xCT in the interaction between mammary cancer and the immune system”.

January 20, 2020. Dr. Roberto Spada Business Development Manager Mass Cytometry Franchise EMEA at Fluidigm, PhD. Seminar MBC, Torino. “Advancing Breakthroughs in Immuno-Oncology Research”

January 31, 2020. Federica Riccardi, Immunology Seminar. “A chimeric CSPG4 DNA vaccine for the treatment of malignant melanoma: a comparative oncology trial for translational medicine”.

February 18, 2020. Miriam Martini, PhD. Cancer Metabolism Club. “Role of PI3K-C2G in pancreatic cancer metabolism and mTOR regulation”

February 18, 2020. Emanuela Pupo. Cancer Metabolism Club. “TBC1D7, a subunit of the TSC1/TSC2 complex, elevates glycolysis and promotes cell motility in breast cancer”

February 21, 2020. Dr. ssa Elisa Giovannetti University di Pisa. “Pharmacology of pancreatic cancer: novel approaches using "solid & liquid" models”

April 27-28, 2020. AACR virtual meeting, “Emerging Signaling Vulnerabilities in Cancer”

April 30, 2020. Anurag Srivastava, Immunology Seminar. “The Cancer-specific High-Throughput Annotation of Somatic Mutations (CHASMplus)”. Elisabetta Bolli, Immunology Seminar. “Development of a VLP-based vaccine displaying an xCT extracellular domain for the treatment of metastatic breast cancer”.

April 14-May 03, 2020. SIICA SCHOOL of IMMUNOLOGY 2020. “Viral Immunology & Vaccinology”.

May 14, 2020. Dr. ssa Chiara Ambrogio, University of Turin. “Insights into KRAS biology to identify novel therapeutic strategies for cancer”.

May 27, 2020. Claudia Curcio, Immunology Seminar. “Effectiveness of ENO1 vaccination in combination with PI3Kg inhibition in PDA treatment”. Giuseppina Barutello, Immunology Seminar. “Combining xCT targeting with APR-246-a new strategy against breast cancer”.

June 22, 2020. Jolanda Magri, Immunology Seminar. “Generation and preliminary characterization of monoclonal antibodies against xCT for the treatment of breast cancer”.

July 8, 2020. Spring Nature Author Seminar, University of Turin. “How to write a scientific paper”.

July 8, 2020. Prof.ssa Grohmann, Webinar series at department of molecular biotechnology and health sciences premise of cancer immunotherapy: where do we stand “"Functional interplay between phosphoinositide 3-kinases (PI3K) and indoleamine 2,3-dioxygenase 1 (IDO1) in immune regulation",

July 15, 2020. Prof. Luca Vannucci, Webinar series at department of molecular biotechnology and health sciences premise of cancer immunotherapy: where do we stand "Immune activation models the tissue stroma: lesson from conventional and germ-free animal models".

July 22, 2020. Prof. Guido Grandi, Webinar series at department of molecular biotechnology and health sciences premise of cancer immunotherapy: where do we stand "Synthetic biology of bacterial outer membrane vesicles (OMVs) for the development of vaccines against”.

July 29, 2020. Prof. Daniela Carnevale, Webinar series at department of molecular biotechnology and health sciences premise of cancer immunotherapy: where do we stand "PI3Kgamma is a molecular switch that controls the immune response involved in hypertension".

February-August, 2020. 30 hours English Intermediate. Centro linguistico The World.

 

January 2018 - July 2019. Torono, Canada. University Health Network, Princess Margaret Cancer Centre.